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Chromosomes, mitosis and the cell cycle: GCSE Combined Science Biology practice questions

Foundation and Higher · Grade 4

A second set of questions on chromosomes, mitosis and the cell cycle. They are different from the ones on the topic page. Try each, then open the answer and compare your working.

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Question 1 Medium

Which stage of the cell cycle happens just before mitosis: growth and DNA copying, or fertilisation?

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Answer: growth and DNA copying

  1. A cell must copy its DNA before it divides.
  2. So the stage before mitosis is growth and DNA copying.

Question 2 Medium

Name the type of tumour that spreads to other parts of the body.

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Answer: malignant

  1. Cancer cells invade other tissues.
  2. This is a malignant tumour.

Question 3 Medium

One cell divides once every 10 minutes. How many cells are there after 40 minutes?

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Answer: 16

  1. 40 minutes = 4 divisions.
  2. 2⁴ = 16.

Question 4 Medium

What word describes a tumour that stays in one place and does not spread?

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Answer: benign

  1. It does not invade other tissues.
  2. This is a benign tumour.

Question 5 Hard

One bacterium divides every 20 minutes. How many bacteria are there after 2 hours?

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Answer: 64

  1. 2 hours = 120 minutes = 6 divisions.
  2. 2⁶ = 64.

Question 6 Hard

A cell has 46 chromosomes. How many chromosomes are in each cell made by mitosis?

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Answer: 46

  1. Mitosis makes identical cells.
  2. So each has 46.

Question 7 Hard

Why are cells made by mitosis all the same? Give one word for what they are.

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Answer: identical

  1. The DNA is copied exactly.
  2. The new cells are genetically identical.

Question 8 Hard

How many cells are there after 7 divisions of one cell?

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Answer: 128

  1. After n divisions there are 2ⁿ cells.
  2. 2⁷ = 128.

Question 9 Medium

In which stage of mitosis do the chromosomes line up along the middle of the cell?

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Answer: metaphase

  1. The chromosomes line up before being pulled apart.
  2. This is metaphase.

Question 10 Hard

In which stage of mitosis are the copies of each chromosome pulled to opposite ends?

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Answer: anaphase

  1. The chromosome copies separate.
  2. This is anaphase.

Quick checks

Short questions with options. Choose one before you open the answer.

Check 1

What is a chromosome?

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A long molecule of DNA that carries many genes.

Check 2

What is a gene?

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A short section of DNA that codes for a protein.

Check 3

How many chromosomes are in a human body cell?

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46, in 23 pairs.

Check 4

What is the cell cycle?

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The series of stages a cell goes through to grow and divide.

Check 5

What happens to organelles before a cell divides?

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The cell grows and makes more of them.

Check 6

When is the DNA copied in the cell cycle?

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Before mitosis, after the cell has grown.

Check 7

What happens during mitosis?

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The copied chromosomes are pulled apart to opposite ends and two nuclei form.

Check 8

What happens after mitosis?

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The cytoplasm and cell membrane divide to make two cells.

Check 9

What are the cells made by mitosis like?

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Genetically identical to each other and to the parent cell.

Check 10

Give three uses of mitosis.

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Growth, repair of damaged tissue and asexual reproduction.

Check 11

What is a clone?

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An organism that is genetically identical to its parent.

Check 12

How many cells are there after 5 divisions of one cell?

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32, because 2⁵ = 32.

Check 13

What is a tumour?

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A lump of cells formed by uncontrolled cell division.

Check 14

What is a benign tumour?

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A tumour that grows in one place and does not spread to other tissues.

Check 15

What is a malignant tumour?

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A cancer that invades other tissues and spreads in the blood.

Check 16

Name two risk factors for cancer.

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Smoking and ultraviolet radiation.

Check 17

Where are the chromosomes in a human body cell?

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In the nucleus.

Check 18

What are the two chromosomes in a pair like?

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They carry the same genes in the same places. One comes from each parent.

Check 19

What is a daughter cell?

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One of the new cells made when a cell divides.

Check 20

How many chromosomes does each daughter cell have after mitosis in humans?

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46, the same as the parent cell.

Check 21

Why does mitosis not cause variation?

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It copies the DNA exactly, so the new cells are clones.

Check 22

What is asexual reproduction?

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Reproduction from one parent, where the offspring are clones.

Check 23

What controls cell division?

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Genes.

Check 24

What do cancer cells do that normal cells do not?

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They divide without control.

Check 25

What is a secondary tumour?

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A new tumour formed where cells from a malignant tumour have spread.

Check 26

Name the stages of mitosis in order.

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Prophase, metaphase, anaphase and telophase, then cytokinesis. Interphase comes before.

Check 27

What happens in metaphase?

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The chromosomes line up along the middle of the cell.

Check 28

What happens in anaphase?

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The two copies of each chromosome are pulled to opposite ends of the cell.

Check 29

What does diploid mean?

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Having two sets of chromosomes.

Keep going with Chromosomes, mitosis and the cell cycle

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