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DNA, the genome and mutations: GCSE Combined Science Biology practice questions

Foundation and Higher ยท Grade 7

A second set of questions on DNA, the genome and mutations. They are different from the ones on the topic page. Try each, then open the answer and compare your working.

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Question 1 Medium

Where in the cell are proteins made?

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Answer: ribosomes

  1. A ribosome joins amino acids.
  2. So proteins are made on ribosomes.

Question 2 Medium

A DNA strand has the bases T G C. Write the complementary strand.

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Answer: A C G

  1. T pairs with A.
  2. G pairs with C, and C pairs with G.

Question 3 Medium

What name is given to a group of three bases that codes for one amino acid?

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Answer: triplet

  1. Bases are read in groups of three.
  2. A group of three is a triplet.

Question 4 Hard

A DNA strand has the bases C T A G G. Write the complementary strand.

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Answer: G A T C C

  1. C pairs with G.
  2. The pairs give G A T C C.

Question 5 Hard

What name is given to a change in the base sequence of DNA?

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Answer: mutation

  1. It happens at random.
  2. It is a mutation.

Question 6 Hard

What determines the shape of a protein?

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Answer: the order of amino acids

  1. The chain folds in a specific way.
  2. The sequence decides the shape.

Question 7 Hard

A mutation is in a non-coding region. Give one thing this could change.

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Answer: gene expression

  1. Non-coding DNA switches genes on and off.
  2. So it affects gene expression.

Quick checks

Short questions with options. Choose one before you open the answer.

Check 1

What is DNA?

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A polymer made of two strands in a double helix, carrying genetic information.

Check 2

What is a nucleotide?

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A repeating unit of DNA made of a sugar, a phosphate and a base.

Check 3

Name the four bases in DNA.

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A, C, G and T.

Check 4

Which bases pair together?

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A with T, and C with G.

Check 5

What is a gene?

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A short section of DNA that codes for a protein.

Check 6

How many bases code for one amino acid?

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Three, called a triplet.

Check 7

What is the genome?

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The entire genetic material of an organism.

Check 8

What was the Human Genome Project?

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A project that mapped all the genes of the human genome.

Check 9

Give one use of knowing the human genome.

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Finding genes linked to diseases.

Check 10

Where are proteins made?

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On ribosomes in the cytoplasm.

Check 11

What decides the shape of a protein?

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The order of its amino acids.

Check 12

What is a mutation?

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A random change in the base sequence of DNA.

Check 13

Why do most mutations have little effect?

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Several triplets can code for the same amino acid.

Check 14

What can non-coding DNA do?

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Switch genes on and off.

Check 15

What is a polymer?

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A long molecule made of many repeating units.

Check 16

Where is DNA found in a cell?

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In the chromosomes in the nucleus.

Check 17

What are the units of DNA called?

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Nucleotides.

Check 18

What does a triplet code for?

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One amino acid.

Check 19

What are proteins made from?

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Chains of amino acids.

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